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淋巴水肿（Lymphedema）是指机体某些部位淋巴液回流受阻引起的软组织液在体表反复感染后皮下纤维结缔组织增生，脂肪硬化，若为肢体则增粗，后期皮肤增厚、粗糙、坚韧如象皮，亦称“象皮肿”。尽管它常常是由癌症治疗和寄生虫感染引起的（继发性淋巴水肿），但也有可能由遗传或出生缺陷引起的（原发性淋巴水肿）。
大约20%采用腋下淋巴清除术的乳腺癌患者患有继发性淋巴水肿。致残和毁容风险显著影响患者生活质量。美国有超过15万人被诊断患有乳腺癌相关淋巴水肿，伴随每年约1.8万人的新增病例，欧洲市场也具有相似的患病人群。继发性淋巴水肿目前用压缩衣、特殊按摩和锻炼缓解，但这些方式只能缓解症状而并非针对淋巴系统损伤的病因，不能治愈该疾病。
LMP1055项目优势及创新性总结
是一个以腺病毒为载体编码的血管内皮生长因子C（VEGR-C）
首个进入临床阶段基因疗法（Ad-VEFG-C）来修复淋巴系统
第一个疾病修饰疗法，治疗乳腺癌术后继发淋巴水肿及其他淋巴水肿
基于可靠的科学研究成果，动物实验（小鼠及猪）证明其有效性及安全性
LMC5000176公司已授权灵麦医药为中国独家项目对接服务机构，如需项目接洽，请联系我们info@lingmed.net 或登录www.lingmed.net/reports 查询其他项目信息。
Gene Therapy for Lymphedema
Lymphedema, is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system, which normally returns interstitial fluid to the thoracic duct, then the bloodstream. The condition can be inherited or can be caused by a birth defect, though it is frequently caused by cancer treatments and by parasitic infections.
According to Lymphatic Education & Research Network (LE&RN), in the USA, there are over 150,000 diagnosed cases of breast cancer associated lymphedema with 18,000 diagnosed new cases of breast cancer associated lymphedema each year. Similar numbers of patients are diagnosed in Europe. Though incurable and progressive, a number of treatments can ameliorate symptoms.
LMP1055 project highlights:
LMP1055 is a gene therapy product: Adenoviral vector coding for Vascular Endothelial Growth Factor C (VEGF-C) intends to reconstitute functional lymphatic system
The world’s first clinical stage gene therapy intending to repair the lymphatic system
First disease modifying therapy aiming to cure lymphedema, including breast cancer associated lymphedema and other lymphedemas
Based on the internationally leading scientific research, pre-clinical data reveal great efficacy and safety of LMP1055
LMC5000176 has grant Lingmed as the exclusive partnering agent in China, if you interested in this project, please contact us info@lingmed.net or visit www.lingmed.net/reports for more available assets.
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